Med Hypotheses 72:2933 McLain AL, Szweda PA, Szweda LI (2011) Alpha-ketoglutarate dehydrogenase: a mitochondrial redox sensor
I genuinely wanted to understand what their reasoning was so I could present a balanced view and write a paragraph or two about it in a blog post to raise awareness and help others advocate for themselves
Currently, in the recruitment phase as of 2024, REDEFINE-3 will use a dosing schedule similar to other REDEFINE and REIMAGINE trials
The compounded medication is prepared in a sterile environment according to compounding standards
Interestingly, the treatment demonstrated dose-dependent therapeutic effects, with moderate dosages proving more effective than high doses (1,000 mg/kg), possibly due to pharmacodynamic principles, where excessive concentrations saturate biological pathways and diminish therapeutic outcomes (Tyagi et al., 2025
10.1155/2018/9390810 133 LiuY.DuanC.ChenH.WangC.LiuX.QiuM.et al (2018b)